From the south (Binghamton): 
Take Route 17 west to exit 65.  Turn right at stop sign.   Bear left at fork in the road, towards Route 17C west.  At traffic light, Holiday Inn Express - Owego is straight ahead or turn right onto Route 17C west and the Owego Treadway Inn and Suites is on the left.

From the northeast (Syracuse): 
Take Route 81 south to Route 17 west.  Then follow above directions.

From the North (Ithaca): 
Take Route 96 south to Owego, New York.   Take Route 17C east for approximately 2 miles.  Owego Treadway Inn and Suites and Holiday Inn Express - Owego are on the right

From the northwest (Buffalo / Rochester): 
Take Route 390 east to Route 17 east to exit 65.  Make a right hand turn at the end of the ramp.  Make a right hand turn at the traffic light.  You will cross over the river.  Bear left at the fork in the road toward Route 17C west.  At the traffic light, Holiday Inn Express - Owego is straight ahead or turn right onto Route 17C and the Owego Treadway Inn and Suites is on the left.

From the east (Albany): 
Take Route 88 west to Binghamton to Route 17 west and then   follow the directions from Binghamton (above).